% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 62 answers for The New York Times crossword clue “___ difference” 4 letters. The answers have between 5 and 15 letters.

AnswerClue
ANGORACATSpets that commonly have different-colored eyes, such as one blue and one amber
AMATTEROFDEGREEnot distinguished by large differences ? or an apt title for this puzzle?
LASSIEfemale dog portrayed by nine different male dogs
PIVOTtry a different tack
RENAMEShandles differently?
HELENmirren who has portrayed three different British queens on screen
TENSEthe difference between who I was and who I am?
WHATITSALLABOUTthe main takeaway ? or, when considered in three different senses, a description of 20-, 33- and 41-Across
HALFBAKEDdescription of 17-, 25-, 36- and 49-Across, in different senses?
MOVEDOVERchange a map of southern England? ? or, when parsed differently, what you need to do to the answers to the starred clues
REFUSEDsaid no … or, interpreted differently, a hint to entering the answers to 16-, 26-, 46- and 61-Across
MARINEBIOLOGISTacademic who works with many different schools, maybe

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