% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 24 answers for The New York Times crossword clue afflicted 3 letters. The answers have between 3 and 10 letters.

AnswerClue
ILLafflicted
DTSalcoholic’s affliction, briefly
WOEaffliction
ALSaffliction for Morrie in “Tuesdays With Morrie,” in brief
AILafflict
THEYIPSathlete’s affliction, informally
STYESeye afflictions
JAUNDICEaffliction treated in newborns with phototherapy
PTSDvet’s affliction
YIPSathlete’s affliction also called “twisties” in gymnastics, with “the”
STYEeye affliction
NOLTEoscar nominee for 1997’s “Affliction
MANGEcanine affliction
STYEocular affliction
STYEaffliction that aptly rhymes with “eye”
STYEeyelid affliction
GOUTaffliction of Benjamin Franklin
STYEaffliction also known as a hordeolum
ROOTROTplant affliction that’s below ground
PTSDaffliction for many a vet
SENIORITISAffliction” for those close to graduation
ACNEskin affliction
STYESafflictions that rhyme with the body parts they’re found in
NOLTEoscar nominee for “The Prince of Tides” and “Affliction

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