% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 11 answers for The New York Times crossword clue headache 4 letters. The answers have between 3 and 15 letters.

AnswerClue
EGOSheadaches for talent agents
PESTheadache
PESTsmall headache
ASPIRINCHANTSthings like “What do we want?” “Headache relief!” “When do we want it?” “Now!”?
LAGgamer’s headache
EARLYFROSTfall farming headache
IBUPROFENheadache helper
RUSHHOURTRAFFICcommuter’s headache [1998, 2000]
OVERBOOKwhat airlines sometimes do, causing headaches
ERRORcoding headache
REDTAPEbusiness headache

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