% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 9 answers for The New York Times crossword clue most despicable. The answers have between 3 and 15 letters.

AnswerClue
DRUgru’s twin brother in the “Despicable Me” franchise
GRUDespicable Me” supervillain
GRUDespicable Me” protagonist
AGNESone of the daughters in “Despicable Me”
GRUDespicable Me” antihero
BASESTmost despicable
GRUthe “me” of “Despicable Me”
MINIONyellow henchman in “Despicable Me”
BENEATHCONTEMPTdespicable … or where this answer goes?

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