% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 9 answers for The New York Times crossword clue most despicable 6 letters. The answers have between 3 and 15 letters.

AnswerClue
MINIONyellow henchman in “Despicable Me”
BASESTmost despicable
GRUDespicable Me” protagonist
AGNESone of the daughters in “Despicable Me”
GRUDespicable Me” antihero
GRUthe “me” of “Despicable Me”
DRUgru’s twin brother in the “Despicable Me” franchise
BENEATHCONTEMPTdespicable … or where this answer goes?
GRUDespicable Me” supervillain

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