% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 10 answers for The New York Times crossword clue optimistic 4 letters. The answers have between 4 and 13 letters.

AnswerClue
ROSYoptimistic
ROSYoptimistic, like an outlook
OPTIMISTone who identifies with the answers to the starred Across clues
UPSIDESoptimists can find them in any situation
HOPESstays optimistic
YESICANconfident shout from an optimist
YOUCANTTHINKstart of an optimistic quote by 57-Across
FALSEHOPEblind optimist’s downfall
HOPESoptimists keep them high
NEVERSAYNEVERperennial optimist’s motto

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