% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 20 answers for The New York Times crossword clue significant 6 letters. The answers have between 3 and 14 letters.

AnswerClue
REDRUM“The Shining” plot device that became significant when read backward
OFNOTEsignificant
AGEGAPsignificant feature of a May-December romance
REDSEAit has a significant part in the Bible
ERAsignificant stretch
NOTEDLYwith significance
OPUSsignificant piece
TRENDone might be statistically significant
PLAYSATRICK“Oh, now I understand the significance of the troupe’s performance in ‘Hamlet’!”
BFSsome significant others, for short
PASSAMILESTONEgo through one of life’s significant moments
DETERIORATEworsen significantly
MINTCOINSETcase made for significant change?
ERAhistorically significant period
OTHERsignificant ___
ERASsignificant stretches
PETUNIAPIGporky’s significant other
TOOKPAINSmade significant efforts
DENTSsignificant impacts, so to speak
EPOCHALhighly significant, as a stretch of time

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