% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 12 answers for The New York Times crossword clue take up again, in a way. The answers have between 3 and 9 letters.

AnswerClue
ONCEDAILYtypical way to take a multivitamin
SITINone way to take a stand, ironically?
ALACARTEone way to take some courses
ROBtake the wrong way?
REPOtake back, in a way
OWEStakes credit, in a way
UBERStakes a car, in a way
REHEMtake up again, in a way
ROLLStakes a turn, in a way
LEASEStakes for a while, in a way
SANDtake the edge off, in a way
FRODOfictional character who says “I will take the ring, though I do not know the way

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