% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 22 answers for The New York Times crossword clue upset 4 letters. The answers have between 3 and 10 letters.

AnswerClue
ROILupset
LEONboxer Spinks who upset Muhammad Ali
UPSETsurprise win
UPSETdiscountenanced
UPSETSknocks over
UPSETSseeds may go down in them
UPSETit can bust one’s bracket
UPSETsurprise ending, of sorts
UPSETwin for a 10-Down
UPSETvictory by a Cinderella team, e.g.
UPSETbig tournament news
UPSETSsurprising wins
SHOCKERupset of the century, say
NONAPOLOGY“It was not my intention to make anyone upset,” often
MOMcry from an upset sibling
GUTmake extremely upset
GINGERALEpopular remedy for an upset stomach
SHALLOWENDcomment like “Sorry you’re upset! Gotta run, late for my nail appointment”?
AOCbronx politician with a noted 2018 upset, familiarly
STUNNERSmajor upsets, e.g.
BENTOUTwith 86-Down, very upset … like the answers to five of this puzzle’s clues?
DEADSILENTlike the loser’s locker room after a stunning upset

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