% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)
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The Crossword Solver found 20 answers for The New York Times crossword clue with significance 7 letters. The answers have between 3 and 14 letters.

AnswerClue
NOTEDLYwith significance
EPOCHALhighly significant, as a stretch of time
DENTSsignificant impacts, so to speak
OFNOTEsignificant
ERAsignificant stretch
OPUSsignificant piece
AGEGAPsignificant feature of a May-December romance
TRENDone might be statistically significant
PLAYSATRICK“Oh, now I understand the significance of the troupe’s performance in ‘Hamlet’!”
BFSsome significant others, for short
PASSAMILESTONEgo through one of life’s significant moments
DETERIORATEworsen significantly
MINTCOINSETcase made for significant change?
REDSEAit has a significant part in the Bible
REDRUM“The Shining” plot device that became significant when read backward
ERAhistorically significant period
OTHERsignificant ___
ERASsignificant stretches
PETUNIAPIGporky’s significant other
TOOKPAINSmade significant efforts

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